GPCRs Neuroscience

Fragile X Syndrome

Fragile X syndrome (FXS) is the most common inherited form of mental disability in addition to a major genetic cause of autism. The symptoms of FXS show many neurological deficits, including low intelligence quotient, seizures, sensory hypersensitivity, social anxiety, hyperactivity and other common to autism. In the mouse model of FXS, the Fmr1 knockout, plasticity …

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Huntington’s Disease

A predominant theory of what leads to HD is the abnormal neurotransmission between the cerebral cortex and the striatum due to alterations in dopamine (DA) modulation of excitation and inhibition in the cortex and basal ganglia. Part of this abnormal neurotransmission may be due to aberrant activation of dopamine D1 receptors in the striatum. Activation …

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Alzheimer’s Disease

Alzheimer’s disease (AD) is a common neurodegenerative disorder causing progressive memory loss and cognitive dysfunction. The amyloid-β precursor protein (APP), which has an unknown role in the brain, has long been suspected to be at the heart of AD. In the brain, APP is broken down into a smaller molecule called amyloid-β. Visible clumps, or …

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ADHD

Many symptoms associated with attention deficit hyperactivity disorder (ADHD) are thought to be due to functional changes in the prefrontal cortex that is involved in signaling via dopamine and adrenaline to interact with their respective G protein-coupled receptors. We seek to identify how these two neurotransmitter pathways interact to drive cognition and identify whether receptor …

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Addiction

One of the more intractable characteristics of drugs of abuse is their ability to subvert the reward system of the individual such that long after contact with the drug the drug-addicted subjects can experience intense drug craving, triggering compulsive drug use. This phenomenon, called cue-induced craving, where exposure to places where the drug-addict may have …

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